Vidalista 80 mg is a member of the PDE5 inhibitor medicine class because it contains tadalafil. These medications prevent the PDE5 enzyme from doing its job. 30 to 60 minutes before engaging in any sexual activity, you can take the medication orally with a glass of water. However, be sure to swallow it whole. Avoid chewing or crushing the medication. It can usually be taken orally with a glass of water. However, always swallow the medication whole rather than chewing or crushing it. If You Don't take it you have used recreational medicines, grapefruit, or alcohol.